| 4. Round | 25/08/2010 | Karlsruher SC II | - | SpVgg Weiden | annull. |  |
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| 6. Round | 05/09/2010 | Eintracht Frankfurt II | - | Karlsruher SC II | 1:1 | ||||
| 7. Round | 11/09/2010 | Karlsruher SC II | - | FSV Frankfurt II | 1:1 | ||||
| 15. Round | 05/11/2010 | Karlsruher SC II | - | 1899 Hoffenheim II | 1:0 | ||||
| 18. Round | 07/12/2010 | SC Freiburg II | - | Karlsruher SC II | 2:1 | |
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| 22. Round | 01/03/2011 | SpVgg Greuther Fürth II | - | Karlsruher SC II | 2:2 | |
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| 24. Round | 12/03/2011 | FSV Frankfurt II | - | Karlsruher SC II | 1:4 | ||||
| 27. Round | 09/04/2011 | Karlsruher SC II | - | SC Pfullendorf | 1:2 |
Germany