| 1. Round | 03/08/2010 | SSV Ulm 1846 | - | Karlsruher SC II | annull. | ||||
| 2. Round | 12/08/2010 | Karlsruher SC II | - | SC Freiburg II | 1:1 | ||||
| 3. Round | 21/08/2010 | Hessen Kassel | - | Karlsruher SC II | 3:2 | ||||
| 4. Round | 25/08/2010 | Karlsruher SC II | - | SpVgg Weiden | annull. | ||||
| 7. Round | 11/09/2010 | Karlsruher SC II | - | FSV Frankfurt II | 1:1 | ||||
| 8. Round | 18/09/2010 | Wormatia Worms | - | Karlsruher SC II | 1:2 | ||||
| 9. Round | 21/09/2010 | Karlsruher SC II | - | FC Memmingen | 1:0 | ||||
| 10. Round | 25/09/2010 | SC Pfullendorf | - | Karlsruher SC II | 1:3 | ||||
| 22. Round | 01/03/2011 | SpVgg Greuther Fürth II | - | Karlsruher SC II | 2:2 | ||||
| 26. Round | 01/04/2011 | FC Memmingen | - | Karlsruher SC II | 2:2 | ||||
| 28. Round | 16/04/2011 | SG Sonnenhof Großaspach | - | Karlsruher SC II | 3:1 | ||||
| 21. Round | 20/04/2011 | Karlsruher SC II | - | Hessen Kassel | 0:0 | ||||
| 29. Round | 23/04/2011 | Karlsruher SC II | - | SV Darmstadt 98 | 1:3 |  |
|||
| 32. Round | 13/05/2011 | 1899 Hoffenheim II | - | Karlsruher SC II | 1:5 | ||||
| 33. Round | 21/05/2011 | Karlsruher SC II | - | TSV 1860 München II | 0:0 | ||||
| 34. Round | 28/05/2011 | SV Wehen Wiesbaden II | - | Karlsruher SC II | 1:0 |
Germany