| 21. Round | 26/01/2025 | Rot-Weiss Essen | - | Hannover 96 II | 5:1 | ||||
| 22. Round | 02/02/2025 | Arminia Bielefeld | - | Rot-Weiss Essen | 1:2 |  |
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| 23. Round | 08/02/2025 | Rot-Weiss Essen | - | SpVgg Unterhaching | 1:1 | ||||
| 24. Round | 15/02/2025 | SV Wehen Wiesbaden | - | Rot-Weiss Essen | 1:3 | ||||
| 25. Round | 22/02/2025 | Rot-Weiss Essen | - | FC Ingolstadt 04 | 2:0 | ||||
| 26. Round | 01/03/2025 | Borussia Dortmund II | - | Rot-Weiss Essen | 0:1 | ||||
| 27. Round | 09/03/2025 | Rot-Weiss Essen | - | Waldhof Mannheim | 1:0 | ||||
| 28. Round | 12/03/2025 | Viktoria Köln | - | Rot-Weiss Essen | 1:0 | ||||
| 29. Round | 15/03/2025 | Rot-Weiss Essen | - | Dynamo Dresden | 1:1 | ||||
| 30. Round | 28/03/2025 | SC Verl | - | Rot-Weiss Essen | 3:0 | |
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| 32. Round | 09/04/2025 | Energie Cottbus | - | Rot-Weiss Essen | 0:1 | ||||
| 33. Round | 12/04/2025 | Rot-Weiss Essen | - | Erzgebirge Aue | 4:2 | ||||
| 35. Round | 26/04/2025 | Rot-Weiss Essen | - | 1. FC Saarbrücken | 0:3 | ||||
| 37. Round | 11/05/2025 | Rot-Weiss Essen | - | VfL Osnabrück | 3:1 | ||||
| 38. Round | 17/05/2025 | VfB Stuttgart II | - | Rot-Weiss Essen | 1:1 |
Germany