| 1. Round | 24/07/2021 | TSV Havelse | - | 1. FC Saarbrücken | 0:1 | ||||
| 2. Round | 31/07/2021 | 1. FC Saarbrücken | - | VfL Osnabrück | 1:2 |  |
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| 3. Round | 14/08/2021 | 1. FC Saarbrücken | - | MSV Duisburg | 2:0 | ||||
| 4. Round | 21/08/2021 | Borussia Dortmund II | - | 1. FC Saarbrücken | 0:0 | ||||
| 5. Round | 25/08/2021 | 1. FC Saarbrücken | - | 1. FC Magdeburg | 2:1 | |
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| 6. Round | 29/08/2021 | Würzburger Kickers | - | 1. FC Saarbrücken | 1:1 | ||||
| 9. Round | 18/09/2021 | 1. FC Saarbrücken | - | Türkgücü München | annull. | ||||
| 10. Round | 25/09/2021 | SV Meppen | - | 1. FC Saarbrücken | 2:2 | ||||
| 16. Round | 19/11/2021 | SC Verl | - | 1. FC Saarbrücken | 2:4 |  |
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| 17. Round | 27/11/2021 | 1. FC Saarbrücken | - | FC Viktoria 1889 Berlin | 2:0 | |
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| 18. Round | 03/12/2021 | FSV Zwickau | - | 1. FC Saarbrücken | 1:2 | ||||
| 19. Round | 11/12/2021 | 1. FC Saarbrücken | - | SC Freiburg II | 1:0 | ||||
| 20. Round | 18/12/2021 | 1. FC Saarbrücken | - | TSV Havelse | 2:2 | ||||
| 22. Round | 23/01/2022 | MSV Duisburg | - | 1. FC Saarbrücken | 3:4 | ||||
| 24. Round | 29/01/2022 | 1. FC Magdeburg | - | 1. FC Saarbrücken | 2:1 |
Germany