| 7. Round | 03/10/2021 | 1. FC Bocholt | - | SpVgg Sterkrade-Nord | 8:0 | ||||
| 8. Round | 10/10/2021 | Schwarz-Weiß Essen | - | 1. FC Bocholt | 0:3 |  |
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| 9. Round | 17/10/2021 | 1. FC Bocholt | - | FC Kray | 3:0 | ||||
| 10. Round | 24/10/2021 | DJK Teutonia St. Tönis | - | 1. FC Bocholt | 0:2 | ||||
| 11. Round | 31/10/2021 | 1. FC Bocholt | - | TuRU Düsseldorf | 4:0 | ||||
| 12. Round | 07/11/2021 | Germania Ratingen 04/19 | - | 1. FC Bocholt | 3:0 |  |
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| 13. Round | 14/11/2021 | 1. FC Bocholt | - | 1. FC Monheim | 6:1 | |
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| 14. Round | 28/11/2021 | 1. FC Mönchengladbach | - | 1. FC Bocholt | 2:4 | ||||
| 15. Round | 05/12/2021 | 1. FC Bocholt | - | FSV Duisburg | 3:0 | |
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| 16. Round | 11/12/2021 | VfB 03 Hilden | - | 1. FC Bocholt | 1:3 | ||||
| 17. Round | 18/12/2021 | 1. FC Bocholt | - | SC Velbert | 5:0 | ||||
| 18. Round | 22/02/2022 | Sportfreunde Niederwenigern | - | 1. FC Bocholt | 2:4 | ||||
| 19. Round | 27/02/2022 | 1. FC Bocholt | - | TV Jahn Hiesfeld | 3:0 | ||||
| 20. Round | 06/03/2022 | SpVg Schonnebeck | - | 1. FC Bocholt | 0:5 | ||||
| 21. Round | 13/03/2022 | 1. FC Bocholt | - | Cronenberger SC | 5:0 |
Germany