| 18. Round | 20/02/2022 | Siegburger SV 04 | - | SV Deutz 05 | 1:2 |  |
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| 19. Round | 23/02/2022 | SV Deutz 05 | - | Spvg Wesseling-Urfeld | 3:1 | ||||
| 21. Round | 24/03/2022 | SV Deutz 05 | - | BC Viktoria Glesch-Paffendorf | 2:2 | ||||
| 23. Round | 27/03/2022 | SV Deutz 05 | - | VfL Alfter | 0:1 | ||||
| 24. Round | 02/04/2022 | SV Deutz 05 | - | VfL 08 Vichttal | 0:2 | ||||
| 25. Round | 10/04/2022 | 1. FC Düren | - | SV Deutz 05 | 3:1 | ||||
| 26. Round | 16/04/2022 | SV Deutz 05 | - | Fortuna Köln II | 2:1 | ||||
| 28. Round | 01/05/2022 | SV Deutz 05 | - | FC Hürth | 2:4 | ||||
| 29. Round | 08/05/2022 | SpVg Frechen 20 | - | SV Deutz 05 | 3:1 | ||||
| 32. Round | 29/05/2022 | SV Deutz 05 | - | SV Bergisch Gladbach 09 | 1:7 | ||||
| 33. Round | 06/06/2022 | SV 1914 Eilendorf | - | SV Deutz 05 | 4:1 | ||||
| 34. Round | 12/06/2022 | SV Deutz 05 | - | Viktoria Arnoldsweiler | 2:5 |
Germany