| 15. Round | 12/02/2006 | 1899 Hoffenheim [Youth] | - | SSV Ulm 1846 [Youth] | 3:1 |  |
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| 16. Round | 19/02/2006 | SC Freiburg [Youth] | - | 1899 Hoffenheim [Youth] | 2:1 | ||||
| 17. Round | 25/02/2006 | 1899 Hoffenheim [Youth] | - | 1. FC Nürnberg [Youth] | 2:0 | ||||
| 19. Round | 12/03/2006 | 1899 Hoffenheim [Youth] | - | TSV 1860 München [Youth] | 0:3 | ||||
| 20. Round | 19/03/2006 | SpVgg Greuther Fürth [Youth] | - | 1899 Hoffenheim [Youth] | 0:0 | ||||
| 21. Round | 25/03/2006 | 1899 Hoffenheim [Youth] | - | VfB Stuttgart [Youth] | 0:4 | ||||
| 22. Round | 02/04/2006 | 1899 Hoffenheim [Youth] | - | Bayern München [Youth] | 0:1 | ||||
| 23. Round | 09/04/2006 | Jahn Regensburg [Youth] | - | 1899 Hoffenheim [Youth] | 1:0 | ||||
| 25. Round | 07/05/2006 | 1. FC Kaiserslautern [Youth] | - | 1899 Hoffenheim [Youth] | 2:1 | ||||
| 26. Round | 14/05/2006 | 1899 Hoffenheim [Youth] | - | Eintracht Trier [Youth] | 9:2 |
Germany