| 1. Round | 19/03/2022 | SV Röchling Völklingen | - | Sportfreunde Eisbachtal | annull. |  |
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| 1. Round | 26/03/2022 | Sportfreunde Eisbachtal | - | SV 07 Elversberg II | 4:0 | ||||
| 2. Round | 03/04/2022 | FC Speyer 09 | - | Sportfreunde Eisbachtal | 1:7 | ||||
| 2. Round | 09/04/2022 | Sportfreunde Eisbachtal | - | FSV Jägersburg | 1:1 | |
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| 2. Round | 23/04/2022 | Sportfreunde Eisbachtal | - | FV Eppelborn | 6:0 | ||||
| 2. Round | 30/04/2022 | Sportfreunde Eisbachtal | - | SV Röchling Völklingen | annull. | ||||
| 3. Round | 04/05/2022 | TSG Pfeddersheim | - | Sportfreunde Eisbachtal | 3:0 | ||||
| 3. Round | 08/05/2022 | SV 07 Elversberg II | - | Sportfreunde Eisbachtal | 1:4 | ||||
| 3. Round | 14/05/2022 | Sportfreunde Eisbachtal | - | FC Speyer 09 | 5:1 |  |
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| 3. Round | 21/05/2022 | FSV Jägersburg | - | Sportfreunde Eisbachtal | 3:3 | ||||
| 3. Round | 28/05/2022 | Sportfreunde Eisbachtal | - | TSG Pfeddersheim | 8:1 | ||||
| 4. Round | 04/06/2022 | FV Eppelborn | - | Sportfreunde Eisbachtal | 1:2 |
Germany