| 1. Round | 13/08/2021 | VfB Oldenburg | - | Werder Bremen II | 3:0 |  |
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| 3. Round | 27/08/2021 | Hannover 96 II | - | VfB Oldenburg | 0:1 |  |
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| 6. Round | 19/09/2021 | Atlas Delmenhorst | - | VfB Oldenburg | 1:2 | |
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| 8. Round | 03/10/2021 | VfB Oldenburg | - | Schwarz-Weiß Rehden | 4:1 | |
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| 5. Round | 06/10/2021 | VfB Oldenburg | - | SSV Jeddeloh II | 3:1 | |
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| 10. Round | 16/10/2021 | Werder Bremen II | - | VfB Oldenburg | 0:0 | ||||
| 7. Round | 20/10/2021 | Lüneburger SK Hansa | - | VfB Oldenburg | 1:1 | ||||
| 11. Round | 24/10/2021 | VfB Oldenburg | - | FC Oberneuland | 3:1 | |
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| 12. Round | 30/10/2021 | VfB Oldenburg | - | Hannover 96 II | 3:1 | ||||
| 13. Round | 07/11/2021 | VfB Oldenburg | - | VfV Hildesheim | 1:2 | ||||
| 14. Round | 13/11/2021 | SSV Jeddeloh II | - | VfB Oldenburg | 0:0 | ||||
| 15. Round | 21/11/2021 | VfB Oldenburg | - | Atlas Delmenhorst | 1:1 | |
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| 16. Round | 28/11/2021 | VfB Oldenburg | - | Lüneburger SK Hansa | 4:0 | |
Germany