| 1. Round | 14/08/2021 | TSV Emmelshausen | - | FC Karbach | 0:6 |  |
|||
| 2. Round | 21/08/2021 | FC Karbach | - | SV Alemannia Waldalgesheim | 1:2 | |
|||
| 3. Round | 25/08/2021 | Eintracht Trier | - | FC Karbach | 4:0 | ||||
| 4. Round | 28/08/2021 | FC Karbach | - | Hassia Bingen | 2:1 | |
|||
| 6. Round | 11/09/2021 | FC Karbach | - | SV Gonsenheim | 2:0 | |
|||
| 7. Round | 18/09/2021 | 1. FC Kaiserslautern II | - | FC Karbach | 3:1 | |
 |
||
| 11. Round | 09/10/2021 | FC Karbach | - | SG Mülheim-Kärlich | 2:1 | |
|||
| 12. Round | 16/10/2021 | FC Karbach | - | TSV Emmelshausen | 2:0 | ||||
| 13. Round | 23/10/2021 | SV Alemannia Waldalgesheim | - | FC Karbach | 0:4 | ||||
| 14. Round | 26/10/2021 | FC Karbach | - | Eintracht Trier | 0:1 | ||||
| 15. Round | 30/10/2021 | Hassia Bingen | - | FC Karbach | 0:3 | |
|||
| 16. Round | 06/11/2021 | FC Karbach | - | Sportfreunde Eisbachtal | 4:4 | |
|||
| 17. Round | 14/11/2021 | SV Gonsenheim | - | FC Karbach | 2:2 | |
|||
| 18. Round | 20/11/2021 | FC Karbach | - | 1. FC Kaiserslautern II | 4:2 | |
|||
| 19. Round | 24/11/2021 | FC Karbach | - | FSV Salmrohr | 1:4 | ||||
| 21. Round | 26/02/2022 | FC Karbach | - | FV Engers 07 | 1:2 |
Germany