| 2. Round | 22/08/2021 | 1. FC Kaiserslautern II | - | FV Engers 07 | 2:1 | ||||
| 3. Round | 25/08/2021 | 1. FC Kaiserslautern II | - | Sportfreunde Eisbachtal | 2:2 |  |
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| 4. Round | 29/08/2021 | SG Mülheim-Kärlich | - | 1. FC Kaiserslautern II | 4:2 |  |
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| 5. Round | 04/09/2021 | 1. FC Kaiserslautern II | - | SV Gonsenheim | 0:1 | ||||
| 1. Round | 07/09/2021 | Hassia Bingen | - | 1. FC Kaiserslautern II | 3:3 | |
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| 6. Round | 11/09/2021 | TSV Emmelshausen | - | 1. FC Kaiserslautern II | 0:3 | |
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| 7. Round | 18/09/2021 | 1. FC Kaiserslautern II | - | FC Karbach | 3:1 | |
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| 8. Round | 22/09/2021 | SV Alemannia Waldalgesheim | - | 1. FC Kaiserslautern II | 1:0 | ||||
| 9. Round | 26/09/2021 | 1. FC Kaiserslautern II | - | FSV Salmrohr | 3:1 | |
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| 10. Round | 02/10/2021 | Eintracht Trier | - | 1. FC Kaiserslautern II | 4:1 | ||||
| 12. Round | 17/10/2021 | 1. FC Kaiserslautern II | - | Hassia Bingen | 0:3 | ||||
| 13. Round | 23/10/2021 | FV Engers 07 | - | 1. FC Kaiserslautern II | 5:0 |  |
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| 15. Round | 30/10/2021 | 1. FC Kaiserslautern II | - | SG Mülheim-Kärlich | 2:1 | ||||
| 21. Round | 20/02/2022 | 1. FC Kaiserslautern II | - | Eintracht Trier | 2:1 | |
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| 22. Round | 05/03/2022 | TuS Koblenz | - | 1. FC Kaiserslautern II | 4:2 | |
Germany
Poland