| 1. Round | 15/08/2021 | VfL Alfter | - | Spvg Wesseling-Urfeld | 3:1 | ||||
| 2. Round | 19/08/2021 | SV Breinig | - | VfL Alfter | 1:2 |  |
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| 3. Round | 22/08/2021 | VfL Alfter | - | BC Viktoria Glesch-Paffendorf | 1:2 | |
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| 4. Round | 29/08/2021 | FC Pesch 1956 | - | VfL Alfter | 1:1 | ||||
| 5. Round | 05/09/2021 | VfL 08 Vichttal | - | VfL Alfter | 1:4 | |
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| 12. Round | 24/10/2021 | VfL Alfter | - | Borussia Freialdenhoven | 3:1 | ||||
| 15. Round | 14/11/2021 | SV 1914 Eilendorf | - | VfL Alfter | 2:0 | |
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| 16. Round | 28/11/2021 | VfL Alfter | - | Viktoria Arnoldsweiler | 2:1 | |
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| 17. Round | 05/12/2021 | Siegburger SV 04 | - | VfL Alfter | 2:0 | ||||
| 23. Round | 27/03/2022 | SV Deutz 05 | - | VfL Alfter | 0:1 | ||||
| 25. Round | 10/04/2022 | Fortuna Köln II | - | VfL Alfter | 1:1 | |
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| 29. Round | 08/05/2022 | Borussia Freialdenhoven | - | VfL Alfter | 2:1 | ||||
| 30. Round | 15/05/2022 | VfL Alfter | - | Blau-Weiß Friesdorf | 1:2 | ||||
| 32. Round | 29/05/2022 | VfL Alfter | - | SV 1914 Eilendorf | 0:1 | ||||
| 33. Round | 06/06/2022 | Viktoria Arnoldsweiler | - | VfL Alfter | 1:1 |
Turkey