| 1. Round | 14/08/2021 | SC Spelle-Venhaus | - | VfL Oldenburg | 1:2 | ||||
| 18. Round | 18/08/2021 | SC Spelle-Venhaus | - | TuS Bersenbrück | 3:0 | ||||
| 2. Round | 22/08/2021 | Rotenburger SV | - | SC Spelle-Venhaus | 0:0 | ||||
| 3. Round | 28/08/2021 | Kickers Emden | - | SC Spelle-Venhaus | 1:1 |  |
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| 4. Round | 05/09/2021 | FC Hagen/Uthlede | - | SC Spelle-Venhaus | 0:3 | ||||
| 6. Round | 19/09/2021 | SC Spelle-Venhaus | - | Blau-Weiß Lohne | 0:2 | ||||
| 11. Round | 24/10/2021 | SC Spelle-Venhaus | - | Rotenburger SV | 5:1 | |
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| 13. Round | 07/11/2021 | SC Spelle-Venhaus | - | FC Hagen/Uthlede | 5:2 | |
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| 14. Round | 14/11/2021 | SC Spelle-Venhaus | - | Heeslinger SC | 2:0 | ||||
| 15. Round | 21/11/2021 | Blau-Weiß Lohne | - | SC Spelle-Venhaus | 1:1 | ||||
| 16. Round | 28/11/2021 | SC Spelle-Venhaus | - | MTV Eintracht Celle | 7:0 | |
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| 17. Round | 04/12/2021 | TB Uphusen | - | SC Spelle-Venhaus | 0:1 |
Germany