| 1. Round | 16/08/1980 | VfB Stuttgart | - | 1. FC Nürnberg | 2:1 | ||||
| 2. Round | 20/08/1980 | 1. FC Nürnberg | - | Hamburger SV | 2:3 | ||||
| 3. Round | 23/08/1980 | TSV 1860 München | - | 1. FC Nürnberg | 2:4 | ||||
| 4. Round | 03/09/1980 | 1. FC Nürnberg | - | VfL Bochum | 0:2 | ||||
| 5. Round | 06/09/1980 | MSV Duisburg | - | 1. FC Nürnberg | 2:0 | ||||
| 6. Round | 13/09/1980 | 1. FC Nürnberg | - | Karlsruher SC | 5:0 |  |
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| 7. Round | 20/09/1980 | 1. FC Nürnberg | - | 1. FC Kaiserslautern | 0:4 | ||||
| 8. Round | 27/09/1980 | 1. FC Köln | - | 1. FC Nürnberg | 2:2 | ||||
| 9. Round | 15/10/1980 | 1. FC Nürnberg | - | Eintracht Frankfurt | 1:4 | ||||
| 10. Round | 18/10/1980 | Bor. Mönchengladbach | - | 1. FC Nürnberg | 1:4 | |
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| 11. Round | 24/10/1980 | 1. FC Nürnberg | - | Bayer 05 Uerdingen | 0:0 | ||||
| 12. Round | 31/10/1980 | Bayern München | - | 1. FC Nürnberg | 4:2 | ||||
| 14. Round | 15/11/1980 | Fortuna Düsseldorf | - | 1. FC Nürnberg | 2:2 | ||||
| 15. Round | 29/11/1980 | 1. FC Nürnberg | - | FC Schalke 04 | 2:0 | ||||
| 19. Round | 24/01/1981 | Hamburger SV | - | 1. FC Nürnberg | 1:0 | ||||
| 21. Round | 14/02/1981 | VfL Bochum | - | 1. FC Nürnberg | 4:0 |
Germany