| 2. Round | 13/02/2022 | VfL Wolfsburg [Youth B] | - | Holstein Kiel [Youth B] | 4:2 |  |
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| 14. Round | 26/02/2022 | Holstein Kiel [Youth B] | - | Dynamo Dresden [Youth B] | 2:4 | ||||
| 15. Round | 05/03/2022 | FC Viktoria 1889 Berlin [Youth B] | - | Holstein Kiel [Youth B] | 4:2 | ||||
| 16. Round | 12/03/2022 | Holstein Kiel [Youth B] | - | Erzgebirge Aue [Youth B] | 0:1 | ||||
| 13. Round | 20/03/2022 | Hannover 96 [Youth B] | - | Holstein Kiel [Youth B] | 1:3 | |
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| 17. Round | 03/04/2022 | RB Leipzig [Youth B] | - | Holstein Kiel [Youth B] | 3:2 | ||||
| 18. Round | 09/04/2022 | Holstein Kiel [Youth B] | - | FC St. Pauli [Youth B] | 0:1 | ||||
| 19. Round | 23/04/2022 | Energie Cottbus [Youth B] | - | Holstein Kiel [Youth B] | 2:2 | |
Germany