| 1. Round | 29/08/2021 | SV Schermbeck | - | Westfalia Herne | 6:0 | ||||
| 2. Round | 05/09/2021 | Westfalia Rhynern | - | SV Schermbeck | 4:0 | ||||
| 3. Round | 12/09/2021 | SV Schermbeck | - | Holzwickeder SC | 2:3 | ||||
| 6. Round | 03/10/2021 | 1. FC Kaan-Marienborn | - | SV Schermbeck | 1:0 | ||||
| 7. Round | 10/10/2021 | SV Schermbeck | - | Viktoria Clarholz | 1:0 | ||||
| 8. Round | 17/10/2021 | TuS Ennepetal | - | SV Schermbeck | 0:0 | ||||
| 10. Round | 31/10/2021 | SV Schermbeck | - | SG Wattenscheid 09 | 1:2 | ||||
| 11. Round | 07/11/2021 | FCE Rheine | - | SV Schermbeck | 5:2 | ||||
| 12. Round | 14/11/2021 | SV Schermbeck | - | TSG Sprockhövel | 2:0 | ||||
| 14. Round | 28/11/2021 | SV Schermbeck | - | Sportfreunde Siegen | 2:3 | ||||
| 15. Round | 05/12/2021 | SpVgg Vreden | - | SV Schermbeck | 0:3 | ||||
| 16. Round | 12/12/2021 | SV Schermbeck | - | FC Gütersloh | 1:0 | ||||
| 18. Round | 06/03/2022 | SV Schermbeck | - | TuS Erndtebrück | 4:0 | ||||
| 17. Round | 10/03/2022 | TuS Haltern | - | SV Schermbeck | 0:2 |  |
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| 21. Round | 27/03/2022 | RSV Meinerzhagen | - | SV Schermbeck | 0:1 |
Germany