| 11. Round | 19/02/2022 | Wuppertaler SV [Youth B] | - | SG Unterrath 12/24 [Youth B] | 1:1 |  |
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| 9. Round | 23/02/2022 | 1. FC Köln [Youth B] | - | Wuppertaler SV [Youth B] | 3:1 | ||||
| 12. Round | 27/02/2022 | Bor. Mönchengladbach [Youth B] | - | Wuppertaler SV [Youth B] | 7:0 | ||||
| 13. Round | 06/03/2022 | Wuppertaler SV [Youth B] | - | Borussia Dortmund [Youth B] | 0:0 | |
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| 14. Round | 13/03/2022 | Fortuna Düsseldorf [Youth B] | - | Wuppertaler SV [Youth B] | 2:0 | ||||
| 15. Round | 03/04/2022 | Wuppertaler SV [Youth B] | - | Arminia Bielefeld [Youth B] | 1:4 |  |
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| 16. Round | 09/04/2022 | Bayer Leverkusen [Youth B] | - | Wuppertaler SV [Youth B] | 4:1 |
Germany