| 10. Round | 17/10/2021 | VfV Hildesheim | - | Lüneburger SK Hansa | 1:1 | ||||
| 11. Round | 23/10/2021 | SSV Jeddeloh II | - | VfV Hildesheim | 3:1 | ||||
| 12. Round | 31/10/2021 | VfV Hildesheim | - | Atlas Delmenhorst | 2:1 | ||||
| 13. Round | 07/11/2021 | VfB Oldenburg | - | VfV Hildesheim | 1:2 |  |
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| 14. Round | 14/11/2021 | VfV Hildesheim | - | Schwarz-Weiß Rehden | 2:0 | |
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| 15. Round | 21/11/2021 | HSC Hannover | - | VfV Hildesheim | 2:3 | ||||
| 16. Round | 28/11/2021 | VfV Hildesheim | - | Werder Bremen II | 1:2 | |
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| 17. Round | 04/12/2021 | FC Oberneuland | - | VfV Hildesheim | 0:3 | |
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| 18. Round | 12/12/2021 | VfV Hildesheim | - | Hannover 96 II | 2:2 |
Germany