| 10. Round | 06/11/2021 | Werder Bremen [Youth B] | - | Hallescher FC [Youth B] | 5:0 | ||||
| 11. Round | 21/11/2021 | 1. FC Union Berlin [Youth B] | - | Werder Bremen [Youth B] | 1:1 | ||||
| 12. Round | 27/11/2021 | Werder Bremen [Youth B] | - | Hannover 96 [Youth B] | 4:3 |  |
|||
| 15. Round | 05/03/2022 | Erzgebirge Aue [Youth B] | - | Werder Bremen [Youth B] | 0:2 | |
|||
| 16. Round | 13/03/2022 | Werder Bremen [Youth B] | - | RB Leipzig [Youth B] | 2:3 | |
|||
| 17. Round | 02/04/2022 | FC St. Pauli [Youth B] | - | Werder Bremen [Youth B] | 2:1 |
Germany