| 1. Round | 15/08/2021 | 1899 Hoffenheim II [Women] | - | SV Henstedt-Ulzburg [Women] | 4:1 |  |
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| 2. Round | 29/08/2021 | RB Leipzig [Women] | - | 1899 Hoffenheim II [Women] | 2:0 | ||||
| 3. Round | 05/09/2021 | 1899 Hoffenheim II [Women] | - | MSV Duisburg [Women] | 1:0 | ||||
| 4. Round | 12/09/2021 | VfL Wolfsburg II [Women] | - | 1899 Hoffenheim II [Women] | 0:0 | ||||
| 8. Round | 07/11/2021 | 1899 Hoffenheim II [Women] | - | SV Meppen [Women] | 0:3 | ||||
| 9. Round | 14/11/2021 | SG 99 Andernach [Women] | - | 1899 Hoffenheim II [Women] | 2:3 | ||||
| 14. Round | 27/02/2022 | SV Henstedt-Ulzburg [Women] | - | 1899 Hoffenheim II [Women] | 1:1 | ||||
| 15. Round | 06/03/2022 | 1899 Hoffenheim II [Women] | - | RB Leipzig [Women] | 0:3 | ||||
| 16. Round | 13/03/2022 | MSV Duisburg [Women] | - | 1899 Hoffenheim II [Women] | 1:1 | ||||
| 19. Round | 03/04/2022 | Bayern München II [Women] | - | 1899 Hoffenheim II [Women] | 1:1 | ||||
| 24. Round | 15/05/2022 | 1899 Hoffenheim II [Women] | - | SV 07 Elversberg [Women] | 0:2 | ||||
| 25. Round | 22/05/2022 | FC Ingolstadt 04 [Women] | - | 1899 Hoffenheim II [Women] | 2:1 | ||||
| 26. Round | 05/06/2022 | 1899 Hoffenheim II [Women] | - | 1. FC Nürnberg [Women] | 4:1 |
USA
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