| 2. Round | 18/09/2021 | Wuppertaler SV [Youth B] | - | Preußen Münster [Youth B] | 0:5 |  |
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| 3. Round | 26/09/2021 | Preußen Münster [Youth B] | - | SG Unterrath 12/24 [Youth B] | 2:1 |  |
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| 4. Round | 03/10/2021 | Bor. Mönchengladbach [Youth B] | - | Preußen Münster [Youth B] | 2:1 | ||||
| 7. Round | 07/11/2021 | Preußen Münster [Youth B] | - | Arminia Bielefeld [Youth B] | 1:0 | ||||
| 8. Round | 27/11/2021 | Bayer Leverkusen [Youth B] | - | Preußen Münster [Youth B] | 2:3 | ||||
| 10. Round | 12/12/2021 | VfL Bochum [Youth B] | - | Preußen Münster [Youth B] | 4:3 | ||||
| 9. Round | 13/02/2022 | Preußen Münster [Youth B] | - | SV Lippstadt 08 [Youth B] | 3:0 | ||||
| 12. Round | 27/02/2022 | Preußen Münster [Youth B] | - | Alemannia Aachen [Youth B] | 2:0 | ||||
| 13. Round | 06/03/2022 | Fortuna Köln [Youth B] | - | Preußen Münster [Youth B] | 1:0 | ||||
| 14. Round | 12/03/2022 | Preußen Münster [Youth B] | - | FC Hennef 05 [Youth B] | 4:1 | ||||
| 17. Round | 23/04/2022 | Rot-Weiss Essen [Youth B] | - | Preußen Münster [Youth B] | 0:0 |
Germany