| 1. Round | 15/08/2021 | Bayern München II [Women] | - | 1. FC Nürnberg [Women] | 0:3 | ||||
| 2. Round | 29/08/2021 | 1. FC Nürnberg [Women] | - | Eintracht Frankfurt II [Women] | 0:0 | ||||
| 3. Round | 05/09/2021 | SV Meppen [Women] | - | 1. FC Nürnberg [Women] | 2:1 | ||||
| 4. Round | 12/09/2021 | 1. FC Nürnberg [Women] | - | SG 99 Andernach [Women] | 4:2 | ||||
| 5. Round | 03/10/2021 | Borussia Bocholt [Women] | - | 1. FC Nürnberg [Women] | 0:4 | ||||
| 6. Round | 10/10/2021 | 1. FC Nürnberg [Women] | - | SV 07 Elversberg [Women] | 0:1 | ||||
| 7. Round | 17/10/2021 | FC Ingolstadt 04 [Women] | - | 1. FC Nürnberg [Women] | 1:2 | ||||
| 8. Round | 07/11/2021 | 1. FC Nürnberg [Women] | - | FSV Gütersloh 2009 [Women] | 0:2 | ||||
| 9. Round | 14/11/2021 | 1. FC Nürnberg [Women] | - | SV Henstedt-Ulzburg [Women] | 2:0 | ||||
| 10. Round | 21/11/2021 | 1. FC Nürnberg [Women] | - | RB Leipzig [Women] | 4:3 | ||||
| 12. Round | 12/12/2021 | VfL Wolfsburg II [Women] | - | 1. FC Nürnberg [Women] | 0:3 | ||||
| 13. Round | 19/12/2021 | 1. FC Nürnberg [Women] | - | 1899 Hoffenheim II [Women] | 1:2 |
Germany