1. Round | 24/07/2021 | TSV Havelse | - | 1. FC Saarbrücken | 0:1 | ||||
2. Round | 31/07/2021 | 1. FC Saarbrücken | - | VfL Osnabrück | 1:2 | ||||
3. Round | 14/08/2021 | 1. FC Saarbrücken | - | MSV Duisburg | 2:0 | ||||
4. Round | 21/08/2021 | Borussia Dortmund II | - | 1. FC Saarbrücken | 0:0 | ||||
5. Round | 25/08/2021 | 1. FC Saarbrücken | - | 1. FC Magdeburg | 2:1 | ||||
6. Round | 29/08/2021 | Würzburger Kickers | - | 1. FC Saarbrücken | 1:1 | ||||
7. Round | 03/09/2021 | 1. FC Saarbrücken | - | SV Wehen Wiesbaden | 3:4 | ||||
12. Round | 16/10/2021 | Hallescher FC | - | 1. FC Saarbrücken | 2:3 | ||||
13. Round | 23/10/2021 | 1. FC Saarbrücken | - | TSV 1860 München | 1:1 | ||||
14. Round | 30/10/2021 | Waldhof Mannheim | - | 1. FC Saarbrücken | 1:0 | ||||
15. Round | 06/11/2021 | 1. FC Saarbrücken | - | 1. FC Kaiserslautern | 0:2 | ||||
16. Round | 19/11/2021 | SC Verl | - | 1. FC Saarbrücken | 2:4 | ||||
18. Round | 03/12/2021 | FSV Zwickau | - | 1. FC Saarbrücken | 1:2 | ||||
20. Round | 18/12/2021 | 1. FC Saarbrücken | - | TSV Havelse | 2:2 |