| 2. Round | 10/08/2012 | Eintracht Trier | - | 1. FSV Mainz 05 II | 2:2 | ||||
| 4. Round | 21/08/2012 | SC Freiburg II | - | 1. FSV Mainz 05 II | 1:1 |  |
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| 5. Round | 25/08/2012 | 1. FC Eschborn | - | 1. FSV Mainz 05 II | 2:1 | ||||
| 6. Round | 01/09/2012 | 1. FSV Mainz 05 II | - | FC 08 Homburg | 1:3 | |
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| 19. Round | 24/11/2012 | SSV Ulm 1846 | - | 1. FSV Mainz 05 II | 2:1 | ||||
| 22. Round | 09/04/2013 | SC Pfullendorf | - | 1. FSV Mainz 05 II | 1:2 |
Germany