| 1. Round | 21/08/2010 | SC Paderborn 07 | - | Erzgebirge Aue | 0:1 | ||||
| 4. Round | 18/09/2010 | Karlsruher SC | - | SC Paderborn 07 | 2:1 | ||||
| 6. Round | 24/09/2010 | Alemannia Aachen | - | SC Paderborn 07 | 2:0 | ||||
| 16. Round | 11/12/2010 | SC Paderborn 07 | - | MSV Duisburg | 0:0 | ||||
| 19. Round | 21/01/2011 | SC Paderborn 07 | - | FC Augsburg | 1:1 | ||||
| 21. Round | 05/02/2011 | SC Paderborn 07 | - | Karlsruher SC | 3:0 | ||||
| 22. Round | 11/02/2011 | Rot-Weiß Oberhausen | - | SC Paderborn 07 | 2:0 | ||||
| 24. Round | 26/02/2011 | Arminia Bielefeld | - | SC Paderborn 07 | 1:1 |  |
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| 25. Round | 05/03/2011 | SC Paderborn 07 | - | Energie Cottbus | 0:5 | ||||
| 33. Round | 08/05/2011 | MSV Duisburg | - | SC Paderborn 07 | 3:1 | ||||
| 34. Round | 15/05/2011 | SC Paderborn 07 | - | TSV 1860 München | 3:2 |
Germany