| 1. Round | 13/08/2021 | TuS Mechtersheim | - | FC Speyer 09 | 3:0 | ||||
| 2. Round | 21/08/2021 | FC Speyer 09 | - | Wormatia Worms | 0:4 | ||||
| 3. Round | 25/08/2021 | FC Speyer 09 | - | TSG Pfeddersheim | 1:0 | ||||
| 5. Round | 06/09/2021 | FC Speyer 09 | - | FV Dudenhofen | 0:6 | ||||
| 6. Round | 12/09/2021 | SV 07 Elversberg II | - | FC Speyer 09 | 2:3 | ||||
| 7. Round | 18/09/2021 | FC Speyer 09 | - | FSV Jägersburg | 0:5 | ||||
| 8. Round | 22/09/2021 | SV Röchling Völklingen | - | FC Speyer 09 | 3:1 | ||||
| 9. Round | 26/09/2021 | FC Speyer 09 | - | FV 07 Diefflen | 3:4 | ||||
| 10. Round | 02/10/2021 | FV Eppelborn | - | FC Speyer 09 | 2:1 |  |
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| 13. Round | 23/10/2021 | Wormatia Worms | - | FC Speyer 09 | 2:0 | ||||
| 15. Round | 31/10/2021 | FC Speyer 09 | - | Arminia Ludwigshafen | 3:4 | ||||
| 16. Round | 08/11/2021 | FV Dudenhofen | - | FC Speyer 09 | 5:2 | ||||
| 17. Round | 14/11/2021 | FC Speyer 09 | - | SV 07 Elversberg II | 2:3 | ||||
| 18. Round | 20/11/2021 | FSV Jägersburg | - | FC Speyer 09 | 4:2 | ||||
| 20. Round | 27/11/2021 | FV 07 Diefflen | - | FC Speyer 09 | 2:1 |
Germany