| 6. Round | 24/10/2021 | Rot-Weiss Essen [Youth] | - | Rot-Weiß Oberhausen [Youth] | 1:0 |  |
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| 7. Round | 31/10/2021 | SC Paderborn 07 [Youth] | - | Rot-Weiss Essen [Youth] | 3:4 | ||||
| 11. Round | 13/02/2022 | FC Schalke 04 [Youth] | - | Rot-Weiss Essen [Youth] | 1:2 | ||||
| 13. Round | 06/03/2022 | Fortuna Düsseldorf [Youth] | - | Rot-Weiss Essen [Youth] | 1:1 | ||||
| 15. Round | 09/04/2022 | Bayer Leverkusen [Youth] | - | Rot-Weiss Essen [Youth] | 1:0 | |
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| 16. Round | 23/04/2022 | Rot-Weiss Essen [Youth] | - | Wuppertaler SV [Youth] | 2:1 | |
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| 17. Round | 30/04/2022 | Borussia Dortmund [Youth] | - | Rot-Weiss Essen [Youth] | 1:0 |
Germany