| 1. Round | 06/08/2021 | SBV Excelsior | - | TOP Oss | 0:1 | ||||
| 2. Round | 13/08/2021 | TOP Oss | - | VVV-Venlo | 2:1 | ||||
| 3. Round | 23/08/2021 | AZ Alkmaar (J) | - | TOP Oss | 1:0 | ||||
| 4. Round | 28/08/2021 | TOP Oss | - | FC Dordrecht | 3:0 | ||||
| 5. Round | 04/09/2021 | Almere City FC | - | TOP Oss | 3:0 | ||||
| 6. Round | 10/09/2021 | TOP Oss | - | ADO Den Haag | 3:3 |  |
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| 7. Round | 17/09/2021 | Roda JC Kerkrade | - | TOP Oss | 2:0 | ||||
| 8. Round | 24/09/2021 | TOP Oss | - | FC Volendam | 2:3 | |
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| 10. Round | 09/10/2021 | FC Eindhoven | - | TOP Oss | 2:1 | ||||
| 12. Round | 22/10/2021 | FC Utrecht (J) | - | TOP Oss | 2:1 | ||||
| 22. Round | 15/01/2022 | ADO Den Haag | - | TOP Oss | 2:0 |
Germany
Algeria