| 4. Round | 20/08/2005 | FC Sochaux | - | Lille OSC | 0:0 | ||||
| 5. Round | 24/08/2005 | Lille OSC | - | Toulouse FC | 0:0 | ||||
| 6. Round | 10/09/2005 | FC Metz | - | Lille OSC | 0:2 | ||||
| 7. Round | 17/09/2005 | Lille OSC | - | OGC Nice | 4:0 | ||||
| 8. Round | 21/09/2005 | Paris Saint-Germain | - | Lille OSC | 2:1 | ||||
| 17. Round | 03/12/2005 | Girondins Bordeaux | - | Lille OSC | 1:0 | ||||
| 18. Round | 10/12/2005 | Lille OSC | - | RC Lens | 0:0 | ||||
| 23. Round | 21/01/2006 | Toulouse FC | - | Lille OSC | 0:0 | ||||
| 27. Round | 18/02/2006 | AS Saint-Étienne | - | Lille OSC | 0:2 | ||||
| 30. Round | 12/03/2006 | FC Nantes | - | Lille OSC | 1:1 | ||||
| 33. Round | 01/04/2006 | Lille OSC | - | AJ Auxerre | 1:1 | ||||
| 34. Round | 08/04/2006 | AS Nancy Lorraine | - | Lille OSC | 0:0 | ||||
| 35. Round | 15/04/2006 | Lille OSC | - | Girondins Bordeaux | 3:2 | ||||
| 36. Round | 29/04/2006 | RC Lens | - | Lille OSC | 4:2 | ||||
| 37. Round | 06/05/2006 | Lille OSC | - | Olympique Lyonnais | 4:0 | ||||
| 38. Round | 13/05/2006 | Stade Rennais | - | Lille OSC | 2:2 |  |
France