| 4. Round | 17/08/2024 | 1. FC Bocholt | - | FC Schalke 04 II | 3:1 | ||||
| 5. Round | 24/08/2024 | FC Schalke 04 II | - | 1. FC Düren | 1:4 | ||||
| 6. Round | 01/09/2024 | 1. FC Köln II | - | FC Schalke 04 II | 4:0 | ||||
| 7. Round | 14/09/2024 | FC Schalke 04 II | - | Bor. Mönchengladbach II | 0:1 | ||||
| 9. Round | 28/09/2024 | FC Schalke 04 II | - | MSV Duisburg | 1:2 | ||||
| 10. Round | 05/10/2024 | Sportfreunde Lotte | - | FC Schalke 04 II | 4:1 | ||||
| 11. Round | 11/10/2024 | FC Schalke 04 II | - | FC Gütersloh | 1:1 | ||||
| 13. Round | 25/10/2024 | FC Schalke 04 II | - | Rot-Weiß Oberhausen | 1:2 | ||||
| 14. Round | 02/11/2024 | Eintracht Hohkeppel | - | FC Schalke 04 II | 2:1 |  |
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| 15. Round | 08/11/2024 | FC Schalke 04 II | - | SC Paderborn 07 II | 0:4 | ||||
| 12. Round | 15/11/2024 | Türkspor Dortmund | - | FC Schalke 04 II | annull. | ||||
| 16. Round | 23/11/2024 | Fortuna Düsseldorf II | - | FC Schalke 04 II | 2:1 | ||||
| 19. Round | 25/01/2025 | KFC Uerdingen 05 | - | FC Schalke 04 II | annull. | ||||
| 20. Round | 01/02/2025 | SV Rödinghausen | - | FC Schalke 04 II | 0:0 |
Germany