| 1. Round | 17/07/2010 | FC Hradec Králové | - | AC Sparta Praha | 2:1 | ||||
| 2. Round | 24/07/2010 | AC Sparta Praha | - | 1. FC Slovácko | 2:1 | ||||
| 3. Round | 01/08/2010 | Dynamo České Budějovice | - | AC Sparta Praha | 1:0 | ||||
| 4. Round | 08/08/2010 | AC Sparta Praha | - | Baník Ostrava | 4:0 | ||||
| 5. Round | 13/08/2010 | 1. FK Příbram | - | AC Sparta Praha | 0:1 | ||||
| 6. Round | 21/08/2010 | AC Sparta Praha | - | Viktoria Plzeň | 0:1 | ||||
| 9. Round | 20/09/2010 | Slavia Praha | - | AC Sparta Praha | 1:2 | ||||
| 14. Round | 30/10/2010 | Bohemians 1905 | - | AC Sparta Praha | 0:1 | ||||
| 16. Round | 13/11/2010 | 1. FC Slovácko | - | AC Sparta Praha | 0:2 | ||||
| 17. Round | 21/11/2010 | AC Sparta Praha | - | Dynamo České Budějovice | 2:0 |
Austria