| 1. Round | 29/08/2021 | Viktoria Clarholz | - | Holzwickeder SC | 1:2 | ||||
| 2. Round | 05/09/2021 | Holzwickeder SC | - | TuS Ennepetal | 2:4 | ||||
| 4. Round | 19/09/2021 | Holzwickeder SC | - | SG Wattenscheid 09 | 1:3 | ||||
| 11. Round | 07/11/2021 | TuS Haltern | - | Holzwickeder SC | 0:1 | ||||
| 12. Round | 14/11/2021 | Holzwickeder SC | - | TuS Erndtebrück | 0:6 | ||||
| 13. Round | 20/11/2021 | Preußen Münster II | - | Holzwickeder SC | 0:3 | ||||
| 15. Round | 05/12/2021 | RSV Meinerzhagen | - | Holzwickeder SC | 4:1 | ||||
| 16. Round | 12/12/2021 | Holzwickeder SC | - | Westfalia Herne | 1:1 | ||||
| 17. Round | 09/03/2022 | Westfalia Rhynern | - | Holzwickeder SC | 2:0 | ||||
| 21. Round | 07/04/2022 | Holzwickeder SC | - | 1. FC Kaan-Marienborn | 1:1 |  |
Germany