| 1. Round | 16/08/2015 | 1. FC Bocholt | - | MSV Duisburg II | 0:2 | ||||
| 2. Round | 23/08/2015 | MSV Duisburg II | - | TV Jahn Hiesfeld | 2:2 | ||||
| 3. Round | 26/08/2015 | MSV Duisburg II | - | TSV Meerbusch | 0:1 | ||||
| 4. Round | 30/08/2015 | Germania Ratingen 04/19 | - | MSV Duisburg II | 3:0 | ||||
| 5. Round | 06/09/2015 | MSV Duisburg II | - | TuRU Düsseldorf | 0:2 | ||||
| 7. Round | 20/09/2015 | MSV Duisburg II | - | SV Hönnepel-Niedermörmter | 3:0 | ||||
| 9. Round | 26/09/2015 | MSV Duisburg II | - | 1. FC Mönchengladbach | 1:1 | ||||
| 10. Round | 04/10/2015 | KFC Uerdingen 05 | - | MSV Duisburg II | 2:0 | ||||
| 11. Round | 11/10/2015 | MSV Duisburg II | - | SpVg Schonnebeck | 2:2 | ||||
| 12. Round | 18/10/2015 | MSV Duisburg II | - | Schwarz-Weiß Essen | 1:2 | ||||
| 15. Round | 15/11/2015 | MSV Duisburg II | - | SC Kapellen-Erft | 0:0 | ||||
| 16. Round | 29/11/2015 | VfR Krefeld-Fischeln | - | MSV Duisburg II | 1:0 |  |
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| 18. Round | 13/12/2015 | MSV Duisburg II | - | 1. FC Bocholt | 3:1 | ||||
| 27. Round | 13/04/2016 | TSV Meerbusch | - | MSV Duisburg II | 1:5 | ||||
| 33. Round | 29/05/2016 | MSV Duisburg II | - | VfR Krefeld-Fischeln | 1:1 |
Germany