| 2. Round | 29/08/2021 | 1. FC Nürnberg [Women] | - | Eintracht Frankfurt II [Women] | 0:0 | ||||
| 6. Round | 10/10/2021 | VfL Wolfsburg II [Women] | - | Eintracht Frankfurt II [Women] | 1:2 |  |
|||
| 9. Round | 14/11/2021 | FSV Gütersloh 2009 [Women] | - | Eintracht Frankfurt II [Women] | 0:1 | |
|||
| 11. Round | 05/12/2021 | SG 99 Andernach [Women] | - | Eintracht Frankfurt II [Women] | 1:1 | ||||
| 12. Round | 12/12/2021 | Eintracht Frankfurt II [Women] | - | Borussia Bocholt [Women] | 3:2 | ||||
| 14. Round | 27/02/2022 | FC Ingolstadt 04 [Women] | - | Eintracht Frankfurt II [Women] | 0:1 | ||||
| 16. Round | 13/03/2022 | SV Henstedt-Ulzburg [Women] | - | Eintracht Frankfurt II [Women] | 1:4 |
Germany