| 1. Round | 11/09/2021 | Fortuna Köln [Youth] | - | Bayer Leverkusen [Youth] | 0:2 | ||||
| 2. Round | 19/09/2021 | Wuppertaler SV [Youth] | - | Fortuna Köln [Youth] | 2:1 | ||||
| 3. Round | 25/09/2021 | Fortuna Köln [Youth] | - | Borussia Dortmund [Youth] | 1:4 | ||||
| 4. Round | 02/10/2021 | Viktoria Köln [Youth] | - | Fortuna Köln [Youth] | 4:0 | ||||
| 5. Round | 16/10/2021 | Fortuna Köln [Youth] | - | Bor. Mönchengladbach [Youth] | 1:1 | ||||
| 6. Round | 24/10/2021 | VfL Bochum [Youth] | - | Fortuna Köln [Youth] | 1:0 | ||||
| 9. Round | 04/12/2021 | Fortuna Köln [Youth] | - | Rot-Weiß Oberhausen [Youth] | 3:0 |  |
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| 12. Round | 20/02/2022 | Fortuna Köln [Youth] | - | MSV Duisburg [Youth] | 2:4 | ||||
| 13. Round | 05/03/2022 | Arminia Bielefeld [Youth] | - | Fortuna Köln [Youth] | 0:2 | |
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| 15. Round | 13/04/2022 | 1. FC Köln [Youth] | - | Fortuna Köln [Youth] | 2:0 | |
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| 16. Round | 23/04/2022 | Fortuna Köln [Youth] | - | Fortuna Düsseldorf [Youth] | 2:3 | |
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| 17. Round | 30/04/2022 | Alemannia Aachen [Youth] | - | Fortuna Köln [Youth] | 1:1 |
Germany