| 2. Round | 04/09/2021 | LB Châteauroux [Youth B] | - | Stade Rennais [Youth B] | 1:1 |  |
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| 4. Round | 19/09/2021 | FC Lorient [Youth B] | - | Stade Rennais [Youth B] | 1:1 | ||||
| 5. Round | 25/09/2021 | Stade Rennais [Youth B] | - | USSA Vertou [Youth B] | 4:1 | |
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| 6. Round | 02/10/2021 | Stade Rennais [Youth B] | - | Stade brestois 29 [Youth B] | 1:0 | ||||
| 7. Round | 10/10/2021 | Chamois Niortais [Youth B] | - | Stade Rennais [Youth B] | 0:0 | ||||
| 8. Round | 16/10/2021 | Stade Rennais [Youth B] | - | EA Guingamp [Youth B] | 2:0 | |
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| 9. Round | 23/10/2021 | VFC La Roche [Youth B] | - | Stade Rennais [Youth B] | 1:1 | ||||
| 12. Round | 27/11/2021 | Stade Rennais [Youth B] | - | Vannes OC [Youth B] | 2:0 | |
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| 13. Round | 04/12/2021 | FC Nantes [Youth B] | - | Stade Rennais [Youth B] | 1:2 | ||||
| 15. Round | 22/01/2022 | SO Cholet [Youth B] | - | Stade Rennais [Youth B] | 2:2 | |
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| 24. Round | 17/04/2022 | Vannes OC [Youth B] | - | Stade Rennais [Youth B] | 0:2 | |
France