| 1. Round | 14/08/2021 | FC Augsburg | - | 1899 Hoffenheim | 0:4 | ||||
| 3. Round | 28/08/2021 | FC Augsburg | - | Bayer Leverkusen | 1:4 | ||||
| 7. Round | 02/10/2021 | Borussia Dortmund | - | FC Augsburg | 2:1 | ||||
| 8. Round | 17/10/2021 | FC Augsburg | - | Arminia Bielefeld | 1:1 | ||||
| 9. Round | 22/10/2021 | 1. FSV Mainz 05 | - | FC Augsburg | 4:1 | ||||
| 15. Round | 10/12/2021 | 1. FC Köln | - | FC Augsburg | 0:2 | ||||
| 16. Round | 15/12/2021 | FC Augsburg | - | RB Leipzig | 1:1 |  |
|||
| 17. Round | 18/12/2021 | SpVgg Greuther Fürth | - | FC Augsburg | 0:0 | ||||
| 18. Round | 08/01/2022 | 1899 Hoffenheim | - | FC Augsburg | 3:1 | ||||
| 21. Round | 05/02/2022 | FC Augsburg | - | 1. FC Union Berlin | 2:0 | ||||
| 22. Round | 12/02/2022 | Bor. Mönchengladbach | - | FC Augsburg | 3:2 | ||||
| 23. Round | 19/02/2022 | FC Augsburg | - | SC Freiburg | 1:2 | ||||
| 24. Round | 27/02/2022 | FC Augsburg | - | Borussia Dortmund | 1:1 |  |
|||
| 25. Round | 04/03/2022 | Arminia Bielefeld | - | FC Augsburg | 0:1 |
Germany