| 11. Round | 20/11/2021 | Erzgebirge Aue [Youth B] | - | Energie Cottbus [Youth B] | 2:2 | ||||
| 5. Round | 23/02/2022 | FC Carl Zeiss Jena [Youth B] | - | Energie Cottbus [Youth B] | 2:0 | ||||
| 12. Round | 02/03/2022 | Energie Cottbus [Youth B] | - | RB Leipzig [Youth B] | 0:6 | ||||
| 15. Round | 06/03/2022 | Energie Cottbus [Youth B] | - | Hertha BSC [Youth B] | 1:1 | ||||
| 16. Round | 12/03/2022 | VfL Wolfsburg [Youth B] | - | Energie Cottbus [Youth B] | 5:0 | ||||
| 13. Round | 26/03/2022 | FC St. Pauli [Youth B] | - | Energie Cottbus [Youth B] | 2:0 | ||||
| 17. Round | 02/04/2022 | Energie Cottbus [Youth B] | - | Eintracht Braunschweig [Youth B] | 3:0 | ||||
| 18. Round | 09/04/2022 | Werder Bremen [Youth B] | - | Energie Cottbus [Youth B] | 5:5 |  |
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| 19. Round | 23/04/2022 | Energie Cottbus [Youth B] | - | Holstein Kiel [Youth B] | 2:2 |  |
Germany