| 1. Round | 23/08/1980 | BFC Dynamo | - | HFC Chemie | 3:0 | ||||
| 2. Round | 30/08/1980 | BSG Sachsenring Zwickau | - | BFC Dynamo | 1:3 |  |
 |
||
| 3. Round | 06/09/1980 | BFC Dynamo | - | 1. FC Lokomotive Leipzig | 3:0 | ||||
| 4. Round | 13/09/1980 | FC Vorwärts Frankfurt/Oder | - | BFC Dynamo | 2:1 | ||||
| 5. Round | 20/09/1980 | BFC Dynamo | - | 1. FC Magdeburg | 1:1 | ||||
| 6. Round | 27/09/1980 | BSG Wismut Aue | - | BFC Dynamo | 0:5 | ||||
| 7. Round | 04/10/1980 | BFC Dynamo | - | Rot-Weiß Erfurt | 7:1 | ||||
| 8. Round | 18/10/1980 | FC Karl-Marx-Stadt | - | BFC Dynamo | 1:2 | ||||
| 9. Round | 25/10/1980 | BFC Dynamo | - | Hansa Rostock | 4:0 | |
|||
| 10. Round | 08/11/1980 | BSG Chemie Böhlen | - | BFC Dynamo | 2:2 | |
|||
| 11. Round | 15/11/1980 | BFC Dynamo | - | Dynamo Dresden | 2:1 | |
|||
| 12. Round | 22/11/1980 | BFC Dynamo | - | BSG Stahl Riesa | 4:1 | ||||
| 13. Round | 29/11/1980 | FC Carl Zeiss Jena | - | BFC Dynamo | 2:2 | ||||
| 17. Round | 14/03/1981 | BFC Dynamo | - | FC Vorwärts Frankfurt/Oder | 1:2 | ||||
| 19. Round | 28/03/1981 | BFC Dynamo | - | BSG Wismut Aue | 5:1 | ||||
| 20. Round | 11/04/1981 | Rot-Weiß Erfurt | - | BFC Dynamo | 3:3 |
Germany