| 11. Round | 08/11/2010 | VfL Osnabrück | - | Karlsruher SC | 0:0 |  |
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| 12. Round | 12/11/2010 | Karlsruher SC | - | Erzgebirge Aue | 1:1 | ||||
| 13. Round | 21/11/2010 | FC Augsburg | - | Karlsruher SC | 3:1 | ||||
| 20. Round | 30/01/2011 | Karlsruher SC | - | Energie Cottbus | 1:0 | ||||
| 21. Round | 05/02/2011 | SC Paderborn 07 | - | Karlsruher SC | 3:0 | ||||
| 22. Round | 13/02/2011 | Karlsruher SC | - | Hertha BSC | 2:6 |
Germany