| 1. Round | 15/08/2021 | Hansa Rostock [Youth B] | - | RB Leipzig [Youth B] | 0:1 | ||||
| 3. Round | 28/08/2021 | FC Carl Zeiss Jena [Youth B] | - | RB Leipzig [Youth B] | 0:3 | ||||
| 4. Round | 10/09/2021 | RB Leipzig [Youth B] | - | Hallescher FC [Youth B] | 1:0 | ||||
| 5. Round | 18/09/2021 | 1. FC Union Berlin [Youth B] | - | RB Leipzig [Youth B] | 3:0 | ||||
| 6. Round | 25/09/2021 | RB Leipzig [Youth B] | - | Hannover 96 [Youth B] | 1:3 | ||||
| 7. Round | 02/10/2021 | Dynamo Dresden [Youth B] | - | RB Leipzig [Youth B] | 1:2 | ||||
| 8. Round | 09/10/2021 | RB Leipzig [Youth B] | - | FC Viktoria 1889 Berlin [Youth B] | 2:3 | ||||
| 13. Round | 19/02/2022 | RB Leipzig [Youth B] | - | Hertha BSC [Youth B] | 1:1 | ||||
| 12. Round | 02/03/2022 | Energie Cottbus [Youth B] | - | RB Leipzig [Youth B] | 0:6 | ||||
| 15. Round | 05/03/2022 | RB Leipzig [Youth B] | - | Eintracht Braunschweig [Youth B] | 3:0 |
Germany