| 1. Round | 06/08/2005 | 1. FC Köln | - | 1. FSV Mainz 05 | 1:0 |  |
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| 2. Round | 14/08/2005 | 1. FSV Mainz 05 | - | Werder Bremen | 0:2 | ||||
| 3. Round | 28/08/2005 | Arminia Bielefeld | - | 1. FSV Mainz 05 | 2:0 | ||||
| 4. Round | 10/09/2005 | 1. FSV Mainz 05 | - | Hamburger SV | 1:3 | ||||
| 7. Round | 24/09/2005 | 1. FSV Mainz 05 | - | Borussia Dortmund | 1:1 | |
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| 9. Round | 15/10/2005 | 1. FSV Mainz 05 | - | Bayer Leverkusen | 3:1 | ||||
| 10. Round | 22/10/2005 | Hertha BSC | - | 1. FSV Mainz 05 | 3:1 | ||||
| 12. Round | 05/11/2005 | Hannover 96 | - | 1. FSV Mainz 05 | 2:2 | ||||
| 15. Round | 04/12/2005 | 1. FSV Mainz 05 | - | VfL Wolfsburg | 5:1 | ||||
| 18. Round | 28/01/2006 | 1. FSV Mainz 05 | - | 1. FC Köln | 4:2 | ||||
| 19. Round | 04/02/2006 | Werder Bremen | - | 1. FSV Mainz 05 | 4:2 | ||||
| 21. Round | 11/02/2006 | Hamburger SV | - | 1. FSV Mainz 05 | 1:0 | |
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| 23. Round | 25/02/2006 | 1. FSV Mainz 05 | - | 1. FC Kaiserslautern | 0:2 | ||||
| 24. Round | 04/03/2006 | Borussia Dortmund | - | 1. FSV Mainz 05 | 1:1 | ||||
| 27. Round | 25/03/2006 | 1. FSV Mainz 05 | - | Hertha BSC | 2:2 | ||||
| 28. Round | 01/04/2006 | 1. FC Nürnberg | - | 1. FSV Mainz 05 | 3:0 | |
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| 29. Round | 08/04/2006 | 1. FSV Mainz 05 | - | Hannover 96 | 0:0 |
Germany
