| 1. Round | 07/08/2010 | Fortuna Düsseldorf II | - | SC Wiedenbrück | 0:1 | ||||
| 2. Round | 21/08/2010 | SC Wiedenbrück | - | Bayer Leverkusen II | 1:3 |  |
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| 3. Round | 28/08/2010 | FC 08 Homburg | - | SC Wiedenbrück | 2:0 |  |
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| 7. Round | 22/09/2010 | SC Verl | - | SC Wiedenbrück | 3:0 | ||||
| 8. Round | 26/09/2010 | SC Wiedenbrück | - | 1. FC Kaiserslautern II | 3:1 | ||||
| 9. Round | 02/10/2010 | Wuppertaler SV | - | SC Wiedenbrück | 2:0 | ||||
| 10. Round | 16/10/2010 | SC Wiedenbrück | - | Preußen Münster | 0:2 | ||||
| 11. Round | 23/10/2010 | Eintracht Trier | - | SC Wiedenbrück | 2:0 | |
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| 13. Round | 06/11/2010 | Borussia Dortmund II | - | SC Wiedenbrück | 2:3 | ||||
| 14. Round | 13/11/2010 | SC Wiedenbrück | - | 1. FSV Mainz 05 II | 2:2 | ||||
| 15. Round | 19/11/2010 | Sportfreunde Lotte | - | SC Wiedenbrück | 1:0 |
Germany