| 15. Round | 28/11/2021 | 1. FC Nürnberg | - | FC St. Pauli | 2:3 | ||||
| 17. Round | 10/12/2021 | FC Schalke 04 | - | 1. FC Nürnberg | 4:1 | ||||
| 18. Round | 18/12/2021 | Erzgebirge Aue | - | 1. FC Nürnberg | 1:3 | ||||
| 19. Round | 15/01/2022 | 1. FC Nürnberg | - | SC Paderborn 07 | 1:2 | ||||
| 20. Round | 21/01/2022 | Fortuna Düsseldorf | - | 1. FC Nürnberg | 0:1 | ||||
| 21. Round | 04/02/2022 | 1. FC Nürnberg | - | FC Ingolstadt 04 | 0:5 | ||||
| 23. Round | 19/02/2022 | 1. FC Nürnberg | - | Jahn Regensburg | 2:0 |  |
|||
| 24. Round | 26/02/2022 | Hansa Rostock | - | 1. FC Nürnberg | 0:2 | |
|||
| 25. Round | 05/03/2022 | 1. FC Nürnberg | - | Hamburger SV | 2:1 | |
 |
||
| 26. Round | 13/03/2022 | Hannover 96 | - | 1. FC Nürnberg | 0:3 | ||||
| 27. Round | 20/03/2022 | 1. FC Nürnberg | - | Dynamo Dresden | 1:1 | ||||
| 28. Round | 03/04/2022 | 1. FC Heidenheim 1846 | - | 1. FC Nürnberg | 3:1 | ||||
| 29. Round | 09/04/2022 | 1. FC Nürnberg | - | SV Darmstadt 98 | 3:1 | |
|||
| 30. Round | 17/04/2022 | Werder Bremen | - | 1. FC Nürnberg | 1:1 | ||||
| 32. Round | 29/04/2022 | FC St. Pauli | - | 1. FC Nürnberg | 1:1 | ||||
| 33. Round | 08/05/2022 | Holstein Kiel | - | 1. FC Nürnberg | 3:0 |
Germany