| 1. Round | 22/08/2021 | Sportfreunde Niederwenigern | - | DJK Teutonia St. Tönis | 4:4 |  |
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| 3. Round | 05/09/2021 | SpVg Schonnebeck | - | DJK Teutonia St. Tönis | 3:0 | ||||
| 4. Round | 12/09/2021 | DJK Teutonia St. Tönis | - | Cronenberger SC | 0:0 | ||||
| 5. Round | 19/09/2021 | SC Union Nettetal | - | DJK Teutonia St. Tönis | 0:1 | ||||
| 7. Round | 03/10/2021 | Sportfreunde Baumberg | - | DJK Teutonia St. Tönis | 4:1 | ||||
| 8. Round | 10/10/2021 | DJK Teutonia St. Tönis | - | 1. FC Kleve | 1:2 | ||||
| 9. Round | 17/10/2021 | TSV Meerbusch | - | DJK Teutonia St. Tönis | 2:1 | ||||
| 10. Round | 24/10/2021 | DJK Teutonia St. Tönis | - | 1. FC Bocholt | 0:2 | ||||
| 11. Round | 29/10/2021 | SSVg Velbert | - | DJK Teutonia St. Tönis | 4:0 | ||||
| 12. Round | 07/11/2021 | DJK Teutonia St. Tönis | - | TVD Velbert | 2:0 |  |
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| 13. Round | 14/11/2021 | SpVgg Sterkrade-Nord | - | DJK Teutonia St. Tönis | 2:3 | |
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| 14. Round | 28/11/2021 | DJK Teutonia St. Tönis | - | Schwarz-Weiß Essen | 0:3 | ||||
| 15. Round | 05/12/2021 | FC Kray | - | DJK Teutonia St. Tönis | 2:3 | ||||
| 17. Round | 18/12/2021 | DJK Teutonia St. Tönis | - | TuRU Düsseldorf | 0:1 | ||||
| 19. Round | 27/02/2022 | DJK Teutonia St. Tönis | - | 1. FC Monheim | 0:2 |
Germany