| 3. Round | 12/09/2021 | FC Gütersloh | - | TuS Haltern | 0:0 | ||||
| 4. Round | 19/09/2021 | TuS Erndtebrück | - | FC Gütersloh | 3:0 | ||||
| 5. Round | 26/09/2021 | FC Gütersloh | - | Preußen Münster II | 4:1 | ||||
| 6. Round | 03/10/2021 | SC Paderborn 07 II | - | FC Gütersloh | 1:1 | ||||
| 7. Round | 10/10/2021 | FC Gütersloh | - | RSV Meinerzhagen | 3:0 | ||||
| 8. Round | 17/10/2021 | Westfalia Herne | - | FC Gütersloh | 1:2 | ||||
| 9. Round | 24/10/2021 | FC Gütersloh | - | Westfalia Rhynern | 2:1 | ||||
| 10. Round | 31/10/2021 | Holzwickeder SC | - | FC Gütersloh | 1:3 |  |
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| 11. Round | 07/11/2021 | FC Gütersloh | - | ASC 09 Dortmund | 1:0 |  |
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| 12. Round | 14/11/2021 | SG Finnentrop/Bamenohl | - | FC Gütersloh | 0:0 | ||||
| 16. Round | 12/12/2021 | SV Schermbeck | - | FC Gütersloh | 1:0 | ||||
| 18. Round | 06/03/2022 | FCE Rheine | - | FC Gütersloh | 0:2 | ||||
| 20. Round | 20/03/2022 | Hammer SpVg | - | FC Gütersloh | 0:0 |
Germany