| 3. Round | 18/04/2022 | RSV Meinerzhagen | - | Holzwickeder SC | 1:3 | ||||
| 4. Round | 24/04/2022 | Holzwickeder SC | - | TSG Sprockhövel | 0:1 | ||||
| 7. Round | 08/05/2022 | Holzwickeder SC | - | Viktoria Clarholz | 2:1 | ||||
| 1. Round | 19/05/2022 | SpVgg Vreden | - | Holzwickeder SC | 3:2 | ||||
| 10. Round | 29/05/2022 | Preußen Münster II | - | Holzwickeder SC | 4:1 |
Germany