| 1. Round | 29/08/2021 | FCE Rheine | - | SC Paderborn 07 II | 1:0 | ||||
| 2. Round | 03/09/2021 | RSV Meinerzhagen | - | FCE Rheine | 1:2 |  |
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| 5. Round | 26/09/2021 | FCE Rheine | - | Holzwickeder SC | 3:0 | ||||
| 7. Round | 10/10/2021 | FCE Rheine | - | SG Finnentrop/Bamenohl | 2:1 | ||||
| 10. Round | 31/10/2021 | TuS Ennepetal | - | FCE Rheine | 4:1 | ||||
| 15. Round | 05/12/2021 | Hammer SpVg | - | FCE Rheine | 2:1 | ||||
| 14. Round | 13/02/2022 | FCE Rheine | - | TSG Sprockhövel | 2:1 | ||||
| 18. Round | 06/03/2022 | FCE Rheine | - | FC Gütersloh | 0:2 | ||||
| 19. Round | 13/03/2022 | TuS Haltern | - | FCE Rheine | 2:3 | ||||
| 17. Round | 16/03/2022 | SpVgg Vreden | - | FCE Rheine | 0:3 | ||||
| 21. Round | 27/03/2022 | Preußen Münster II | - | FCE Rheine | 3:1 | ||||
| 20. Round | 03/04/2022 | FCE Rheine | - | TuS Erndtebrück | 2:0 |
Germany