| 1. Round | 06/08/2022 | 1. FC Union Berlin | - | Hertha BSC | 3:1 | ||||
| 2. Round | 14/08/2022 | 1. FSV Mainz 05 | - | 1. FC Union Berlin | 0:0 | ||||
| 3. Round | 20/08/2022 | 1. FC Union Berlin | - | RB Leipzig | 2:1 | ||||
| 4. Round | 27/08/2022 | FC Schalke 04 | - | 1. FC Union Berlin | 1:6 | ||||
| 5. Round | 03/09/2022 | 1. FC Union Berlin | - | Bayern München | 1:1 | ||||
| 6. Round | 11/09/2022 | 1. FC Köln | - | 1. FC Union Berlin | 0:1 | ||||
| 7. Round | 18/09/2022 | 1. FC Union Berlin | - | VfL Wolfsburg | 2:0 | ||||
| 8. Round | 01/10/2022 | Eintracht Frankfurt | - | 1. FC Union Berlin | 2:0 | ||||
| 9. Round | 09/10/2022 | VfB Stuttgart | - | 1. FC Union Berlin | 0:1 |  |
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| 11. Round | 23/10/2022 | VfL Bochum | - | 1. FC Union Berlin | 2:1 |  |
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| 15. Round | 13/11/2022 | SC Freiburg | - | 1. FC Union Berlin | 4:1 | ||||
| 16. Round | 21/01/2023 | 1. FC Union Berlin | - | 1899 Hoffenheim | 3:1 | ||||
| 27. Round | 08/04/2023 | Borussia Dortmund | - | 1. FC Union Berlin | 2:1 | ||||
| 28. Round | 16/04/2023 | 1. FC Union Berlin | - | VfL Bochum | 1:1 |  |
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| 31. Round | 06/05/2023 | FC Augsburg | - | 1. FC Union Berlin | 1:0 | |
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| 33. Round | 20/05/2023 | 1899 Hoffenheim | - | 1. FC Union Berlin | 4:2 |
Germany