| 18. Round | 17/01/2010 | FC Schalke 04 | - | 1. FC Nürnberg | 1:0 | ||||
| 23. Round | 21/02/2010 | VfL Wolfsburg | - | FC Schalke 04 | 2:1 | ||||
| 24. Round | 26/02/2010 | FC Schalke 04 | - | Borussia Dortmund | 2:1 | ||||
| 25. Round | 06/03/2010 | Eintracht Frankfurt | - | FC Schalke 04 | 1:4 | ||||
| 26. Round | 12/03/2010 | FC Schalke 04 | - | VfB Stuttgart | 2:1 | ||||
| 27. Round | 21/03/2010 | Hamburger SV | - | FC Schalke 04 | 2:2 |  |
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| 28. Round | 27/03/2010 | Bayer Leverkusen | - | FC Schalke 04 | 0:2 | ||||
| 29. Round | 03/04/2010 | FC Schalke 04 | - | Bayern München | 1:2 | ||||
| 30. Round | 10/04/2010 | Hannover 96 | - | FC Schalke 04 | 4:2 | ||||
| 31. Round | 17/04/2010 | FC Schalke 04 | - | Bor. Mönchengladbach | 3:1 | ||||
| 32. Round | 24/04/2010 | Hertha BSC | - | FC Schalke 04 | 0:1 | ||||
| 33. Round | 01/05/2010 | FC Schalke 04 | - | Werder Bremen | 0:2 | ||||
| 34. Round | 08/05/2010 | 1. FSV Mainz 05 | - | FC Schalke 04 | 0:0 |
Germany